Tapentadol is partly metabolized with the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medication that enrich or repress the activity/expression of a number of of such enzymes, and also with substrates of those enzymes (resulting from competition to the enzyme); some enzyme mediators/substrates require dosing https://franzj665hzq7.life-wiki.com/user