Remedy of numerous myeloma cells with VLX1570 induced the accumulation of proteasome-bound high molecular pounds polyubiquitin conjugates and an apoptotic response. Sensitivity to VLX1570 was moderately affected by altered drug uptake, but was unaffected by overexpression of BCL2-family proteins or inhibitors of caspase activity. At last, treatment with VLX1570 was https://mitchg308zeh0.wikiannouncement.com/user