DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes through three nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal constructions of DNA ligases sure to nucleotide and nucleic acid substrates have illuminate... https://jeffl481jnq1.wikicommunication.com/user