Chemotherapy was potentiated by E7449 and single agent had considerable antitumor action in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, probably as a result of TNKS inhibition. Consistent with this possibility, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and significantly altered expression of https://letitiaa075tyc8.jasperwiki.com/user